Doctor recommended

Bupropion + Gum

First month: $50 $87/month
+ one time $15 online physician visit

Zero’s smoking-cessation program is a 12-week course combining prescription bupropion and nicotine gum. The combination of bupropion and nicotine therapy can increase chances of successfully quitting by over 3x. *

The Rx + Gum

The combination of prescription bupropion and nicotine replacement therapy can increase your chances of successfully quitting by over 3x. *

Curb cravings

Prescription bupropion helps curb cravings and make nicotine less desirable.

Reduce withdrawal symptoms

Nicotine gum can help reduce withdrawal symptoms like restlessness, irritability and anxiety.

Continued support

Use the Zero Quit Smoking Tracker app to log your progress and find resources.

12-week program

Studies show using bupropion for 7-12 weeks with nicotine therapy results in the greatest chance for long-term success with this treatment plan.

Make new habits

Treatment relieves symptoms so you can break old habits and build new healthy ones.

Access to a doctor

Ask your doctor questions any time through your My Ro account.

From our community

Quitter testimonials

In only 4 Days I didn’t feel the urge to pick up a cigarette or take a pull of my e-cigarette…at all! It’s been two weeks now and I am still smoke-free, cigarette free, and e-cigarette free.
Justin H
Boston, MA
I went from 15 years smoking, to 41 days not smoking and that’s huge. And I really thank Zero for that.
James N
East Stroudsburg, PA
I'd still be smoking without Zero, plain and simple. The medication, gum, app combo helped me quit for good.
Mike S
Zero Quitter, New York, NY
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The details

Medical information

Bupropion

About Bupropion

Bupropion is a smoking cessation aid that can help reduce nicotine cravings and withdrawal symptoms. For smoking cessation, bupropion is prescribed for a 12-week course.

Learn — Bupropion Medical Facts

How does it work?

The action of bupropion is not fully understood, but we know bupropion blocks the neurotransmitters dopamine and norepinephrine from being reabsorbed, which means they hang around and work longer.

Bupropion seems to affect these two important neurotransmitters in a way that is similar to nicotine, which can decrease your withdrawal symptoms when you are trying to quit. Bupropion also weakly blocks the nicotine receptor (the place on a nerve cell where a chemical lands to transmit its message), which makes nicotine less desirable. This helps prevent relapse when former smokers are trying to make their new non-smoking lifestyle stick.

How is it used?

Bupropion should be started at least one week before you quit smoking. Bupropion should be taken once daily for the first 3 days, to allow your body to adjust. It should then taken twice daily for the 12 weeks.

What are the possible side effects?

The most common side effects of bupropion include: agitation, dry mouth, insomnia, headache/migraine, nausea/vomiting, constipation, tremor, dizziness, excessive sweating, blurred vision, tachycardia (rapid heart rate), confusion, rash, hostility, cardiac arrhythmia (irregular heartbeat), and auditory disturbance

Bupropion is generally very safe, but all medicines have the potential for causing side effects. Rarely, these can be serious, and you need to know about them.

Bupropion has a black box warning about a potential for increased risk of suicidal thoughts and behaviors. This increased risk is seen in patients up to age 24. It’s important to remember that bupropion is primarily used as an antidepressant, and people with depression are at higher risk of suicidal thoughts and behaviors. However, it’s possible that bupropion taken for other reasons, like smoking cessation, might also have this increased risk

Learn more about bupropion, its potential benefits, and its potentional side effects here

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Nicotine Gum

About Nicotine gum

Nicotine gum is a form of nicotine replacement therapy (NRT). Nicotine replacements can help reduce withdrawal symptoms like restlessness, irritability and anxiety.

How does it work?

Nicotine gum delivers a dose of nicotine to your system, without the dangerous chemicals in cigarette smoke. A nicotine replacement doesn’t reproduce the precise effect of smoking because it delivers the nicotine to your system more slowly, and in lower amounts, than cigarettes. It helps dulls the withdrawal symptoms like irritability and restlessness that distress quitters.

How is it used?

Nicotine gum should be started on your target quit date, and continued for at least the first 8 weeks. For the first six weeks, doctors recommend using 1 piece every 1-2 hours. After the first six weeks, you can taper your use to wean yourself off nicotine.

The gum is not chewed like bubble gum. Instead, you should chew it slowly until you can taste the flavor. Most people describe a tingling sensation. Then you should stop chewing and park the piece between your cheek and gum. Every once in a while (1-5 minutes), give the gum another few chews to release a bit more nicotine.

What are the possible risks of nicotine gum?

Nicotine gum should not be used while you are still smoking. This can lead to nicotine poisoning. And, while this may seem obvious, nicotine gum is a medicine and should be kept away from children. Even a piece of used gum can be toxic to children or pets. Gum is tempting to children so when you are done with a piece of gum, dispose of it in a manner that makes it impossible for children or pets to reach. These are just some of the symptoms of nicotine poisoning: headaches, hearing or vision problems, confusion, tremors, dizziness, weakness, abdominal pain, vomiting diarrhea, nausea, flushing, sweating, salivation, low blood pressure, irregular heart rate, shortness of breath or other breathing difficulties.

If you suspect nicotine poisoning call (800) 222-1222 — The United States National Poison Hotline — and go to the nearest emergency room.

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Frequently Asked Questions

Still didn’t find your answer? Please reach out to our care team at care@ro.co

What if I don’t want a prescription?
No problem. The way you choose to quit is entirely up to you, and you can select this preference during your online doctor visit.

With that being said, multicomponent therapy has been shown to be superior for successful quitting compared to single component therapy.
Are there any side effects of bupropion?
According to the Physician’s Desk Reference (PDR) common reactions may include “agitation, dry mouth, insomnia, headache/migraine, nausea/vomiting, constipation, tremor, dizziness, excessive sweating, blurred vision, tachycardia (rapid heart rate), confusion, rash, hostility, cardiac arrhythmia (irregular heartbeat), and auditory disturbance.
Is this medication sold only by Zero?
Zero is the only online smoking cessation solution that uses multicomponent therapy to help you quit smoking. Part of this treatment includes the use of bupropion which can be prescribed by other doctors and sold by other pharmacies.
Can I use my insurance?
Not at the moment, but hang tight! We are working to allow for insurance coverage in the near future.

This medication may be covered by insurance though (inclusive of Medicaid and Medicare) when sold by other providers.

Other ways to quit

Our product offerings

The Medication

Bupropion

First month: $8 $52/month
+ one time $15 online physician visit
Prescription bupropion is a smoking cessation aid that can help reduce nicotine cravings and withdrawal symptoms.
Learn more Get the medication

Nicotine replacement therapy

Nicotine Gum

First month: $5 $42/month
Nicotine gum is a nicotine replacement therapy (NRT) that can help reduce withdrawal symptoms like restlessness, irritability and anxiety.
Learn more Get the gum

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