Bupropion + Gum
Zero’s smoking-cessation program is a 12-week course combining prescription bupropion and nicotine gum. The combination of bupropion and nicotine therapy can increase chances of successfully quitting by over 3x. *
Important safety informationThe Rx + Gum
The combination of prescription bupropion and nicotine replacement therapy can increase your chances of successfully quitting by over 3x. *
Curb cravings
Reduce withdrawal symptoms
12-week program
Make new habits
Access to a doctor
From our community
Quitter testimonials
In only 4 Days I didn’t feel the urge to pick up a cigarette or take a pull of my e-cigarette…at all! It’s been two weeks now and I am still smoke-free, cigarette free, and e-cigarette free.
I went from 15 years smoking, to 41 days not smoking and that’s huge. And I really thank Zero for that.
I'd still be smoking without Zero, plain and simple. The medication, gum, app combo helped me quit for good.
The details
Medical information
Bupropion
About Bupropion
Bupropion is a smoking cessation aid that can help reduce nicotine cravings and withdrawal symptoms. For smoking cessation, bupropion is prescribed for a 12-week course.
Learn — Bupropion Medical Facts
How does it work?
The action of bupropion is not fully understood, but we know bupropion blocks the neurotransmitters dopamine and norepinephrine from being reabsorbed, which means they hang around and work longer.
Bupropion seems to affect these two important neurotransmitters in a way that is similar to nicotine, which can decrease your withdrawal symptoms when you are trying to quit. Bupropion also weakly blocks the nicotine receptor (the place on a nerve cell where a chemical lands to transmit its message), which makes nicotine less desirable. This helps prevent relapse when former smokers are trying to make their new non-smoking lifestyle stick.
How is it used?
Bupropion should be started at least one week before you quit smoking. Bupropion should be taken once daily for the first 3 days, to allow your body to adjust. It should then taken twice daily for the 12 weeks.
What are the possible side effects?
The most common side effects of bupropion include: agitation, dry mouth, insomnia, headache/migraine, nausea/vomiting, constipation, tremor, dizziness, excessive sweating, blurred vision, tachycardia (rapid heart rate), confusion, rash, hostility, cardiac arrhythmia (irregular heartbeat), and auditory disturbance
Bupropion is generally very safe, but all medicines have the potential for causing side effects. Rarely, these can be serious, and you need to know about them.
Bupropion has a black box warning about a potential for increased risk of suicidal thoughts and behaviors. This increased risk is seen in patients up to age 24. It’s important to remember that bupropion is primarily used as an antidepressant, and people with depression are at higher risk of suicidal thoughts and behaviors. However, it’s possible that bupropion taken for other reasons, like smoking cessation, might also have this increased risk
Learn more about bupropion, its potential benefits, and its potentional side effects here
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Nicotine Gum
About Nicotine gum
Nicotine gum is a form of nicotine replacement therapy (NRT). Nicotine replacements can help reduce withdrawal symptoms like restlessness, irritability and anxiety.
How does it work?
Nicotine gum delivers a dose of nicotine to your system, without the dangerous chemicals in cigarette smoke. A nicotine replacement doesn’t reproduce the precise effect of smoking because it delivers the nicotine to your system more slowly, and in lower amounts, than cigarettes. It helps dulls the withdrawal symptoms like irritability and restlessness that distress quitters.
How is it used?
Nicotine gum should be started on your target quit date, and continued for at least the first 8 weeks. For the first six weeks, doctors recommend using 1 piece every 1-2 hours. After the first six weeks, you can taper your use to wean yourself off nicotine.
The gum is not chewed like bubble gum. Instead, you should chew it slowly until you can taste the flavor. Most people describe a tingling sensation. Then you should stop chewing and park the piece between your cheek and gum. Every once in a while (1-5 minutes), give the gum another few chews to release a bit more nicotine.
What are the possible risks of nicotine gum?
Nicotine gum should not be used while you are still smoking. This can lead to nicotine poisoning. And, while this may seem obvious, nicotine gum is a medicine and should be kept away from children. Even a piece of used gum can be toxic to children or pets. Gum is tempting to children so when you are done with a piece of gum, dispose of it in a manner that makes it impossible for children or pets to reach. These are just some of the symptoms of nicotine poisoning: headaches, hearing or vision problems, confusion, tremors, dizziness, weakness, abdominal pain, vomiting diarrhea, nausea, flushing, sweating, salivation, low blood pressure, irregular heart rate, shortness of breath or other breathing difficulties.
If you suspect nicotine poisoning call (800) 222-1222 — The United States National Poison Hotline — and go to the nearest emergency room.
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Frequently Asked Questions
Still didn’t find your answer? Please reach out to our care team at care@ro.co
With that being said, multicomponent therapy has been shown to be superior for successful quitting compared to single component therapy.
This medication may be covered by insurance though (inclusive of Medicaid and Medicare) when sold by other providers.
Other ways to quit
Our product offerings
The Medication
Bupropion
Nicotine replacement therapy